Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247624 | 0.93 | THRB (0.37) | THRBALDH1A1KDM4EGAALMNA | |
| SCHEMBL1246439 | 0.91 | PPARD (0.37) | ALDH1A1DGAT1SOAT1FFAR4MEN1 | |
| SCHEMBL1247343 | 0.90 | PTGS2 (0.42) | NPC1FFAR4RXRARXRBRXRG | |
| SCHEMBL1245270 | 0.89 | KDM4E (0.44) | ALDH1A1KDM4EGAALMNAHPGD | |
| SCHEMBL1247569 | 0.86 | SCN9A (0.39) | KDM4ENPC1DGAT1CACNA1FCACNA1D | |
| SCHEMBL2337987 | 0.85 | LPAR1 (0.40) | DGAT1SOAT1RXRARXRBRXRG | |
| SCHEMBL1247291 | 0.85 | SCN9A (0.41) | KDM4EGAALMNANPC1DGAT1 | |
| SCHEMBL1247301 | 0.84 | PPARD (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL1246323 | 0.83 | PPARD (0.39) | ALDH1A1KDM4EGAALMNAHPGD | |
| SCHEMBL1247349 | 0.83 | GPBAR1 (0.39) | ALDH1A1KDM4EGAALMNADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |