Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245262 | 0.91 | THRB (0.37) | FFAR4ALDH1A1MEN1KMT2ADGAT1 | |
| SCHEMBL1247301 | 0.91 | PPARD (0.41) | PPARDNR1H4ALDH1A1GPBAR1MEN1 | |
| SCHEMBL1247343 | 0.89 | PTGS2 (0.42) | PPARDFFAR4MEN1KMT2A | |
| SCHEMBL1247624 | 0.88 | THRB (0.37) | FFAR4ALDH1A1GPBAR1MEN1KMT2A | |
| SCHEMBL1245270 | 0.87 | KDM4E (0.44) | PPARDNR1H4SCN9AALDH1A1GPBAR1 | |
| SCHEMBL2337495 | 0.86 | LPAR1 (0.40) | PPARDFFAR4NR1H4PPARGPPARA | |
| SCHEMBL1247569 | 0.85 | SCN9A (0.39) | PPARDNR1H4SCN9AMAPTDGAT1 | |
| SCHEMBL1245358 | 0.84 | NR1H4 (0.42) | PPARDNR1H4SCN9AALDH1A1GPBAR1 | |
| SCHEMBL1247291 | 0.83 | SCN9A (0.41) | PPARDNR1H4SCN9AMAPTDGAT1 | |
| SCHEMBL1246323 | 0.82 | PPARD (0.39) | PPARDNR1H4PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |