SCHEMBL12460485

SCHEMBL12460485

CC(C)(C)OC(=O)COC(CC1CC2C=CC1C2)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.32
POLB P06746 1/20 0.32
ALOX15 P16050 1/20 0.32
ALDH1A1 P00352 3/20 0.31
TDP1 Q9NUW8 1/20 0.31
MAPT P10636 1/20 0.30
PKM P14618 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3364020 0.84 KDM4E (0.33) KDM4EPOLBALOX15ALDH1A1TDP1
SCHEMBL14468756 0.83 KDM4E (0.36) KDM4EPOLBALOX15ALDH1A1TDP1
SCHEMBL14468501 0.83 KDM4E (0.36) KDM4EPOLBALOX15ALDH1A1TDP1
SCHEMBL24355008 0.80 KDM4E (0.34) KDM4EPOLBALOX15ALDH1A1TDP1
SCHEMBL3363142 0.79 KDM4E (0.35) KDM4EPOLBALOX15ALDH1A1TDP1
SCHEMBL14448861 0.79 CYP11B1 (0.31) ALDH1A1TDP1
SCHEMBL14448866 0.78
SCHEMBL6423573 0.78 KDM4E (0.38) KDM4EPOLBALOX15ALDH1A1TDP1
SCHEMBL3367438 0.76 KDM4E (0.33) KDM4EPOLBALOX15ALDH1A1TDP1
SCHEMBL4379431 0.76 KDM4E (0.38) KDM4EPOLBALOX15ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8753790-B2 Self-imageable film forming polymer, compositions thereof and devices and structures made therefrom PROMERUS, LLC (US) 2014-06-17 US disclosed
US-8753790-B2 Self-imageable film forming polymer, compositions thereof and devices and structures made therefrom PROMERUS, LLC (US) 2014-06-17 US disclosed
EP-2448991-B1 A SELF-IMAGEABLE FILM FORMING POLYMER, COMPOSITIONS THEREOF AND DEVICES AND STRUCTURES MADE THEREFROM PROMERUS LLC (US) 2014-02-26 EP disclosed
US-8329838-B2 Norbornene-type polymers, compositions thereof and lithographic processes using such compositions PROMERUS LLC (US) 2012-12-11 US disclosed
US-8329838-B2 Norbornene-type polymers, compositions thereof and lithographic processes using such compositions PROMERUS LLC (US) 2012-12-11 US disclosed
EP-1853972-B1 NORBORNENE-TYPE POLYMERS AND THEIR MANUFACTURE PROCESS PROMERUS LLC (US) 2011-07-20 EP disclosed
US-20110104614-A1 Self-imageable film forming polymer, compositions thereof and devices and structures made therefrom PROMERUS LLC 2011-05-05 US disclosed
US-20110104614-A1 Self-imageable film forming polymer, compositions thereof and devices and structures made therefrom PROMERUS LLC 2011-05-05 US disclosed
US-20110065878-A1 Norbornene-Type Polymers, Compositions Thereof And Lithographic Processes Using Such Compositions PROMERUS LLC (US) 2011-03-17 US disclosed
US-20110065878-A1 Norbornene-Type Polymers, Compositions Thereof And Lithographic Processes Using Such Compositions PROMERUS LLC (US) 2011-03-17 US disclosed
US-20100099906-A1 GENERATION OF ENDO- AND/OR EXO-NORBORNENECARBOXALDEHYDE AS AN INTERMEDIATE TO FUNCTIONALIZED NORBORNENES PROMERUS LLC (US) 2010-04-22 US disclosed
US-7662996-B2 forming diastereomeric mixture of norbornenecarbonitrile via Diels-Alder reaction, separating, converting to diastereomeric norbornenecarboxaldehyde, and norbornenecarboxylic acid and alcohol; methathesis ring-opening polymerization PROMERUS, LLC (US) 2010-02-16 US disclosed
US-7662996-B2 forming diastereomeric mixture of norbornenecarbonitrile via Diels-Alder reaction, separating, converting to diastereomeric norbornenecarboxaldehyde, and norbornenecarboxylic acid and alcohol; methathesis ring-opening polymerization PROMERUS, LLC (US) 2010-02-16 US disclosed
WO-2009061723-A1 GENERATION OF ENDO- AND/OR EXO-NORBORNENECARBOXALDEHYDE AS AN INTERMEDIATE TO FUNCTIONALIZED NORBORNENES PROMERUS, LLC (US) 2009-05-14 WO disclosed
US-20090118539-A1 forming diastereomeric mixture of norbornenecarbonitrile via Diels-Alder reaction, separating, converting to diastereomeric norbornenecarboxaldehyde, and norbornenecarboxylic acid and alcohol; methathesis ring-opening polymerization PROMERUS, LLC (US) 2009-05-07 US disclosed
US-20090118539-A1 forming diastereomeric mixture of norbornenecarbonitrile via Diels-Alder reaction, separating, converting to diastereomeric norbornenecarboxaldehyde, and norbornenecarboxylic acid and alcohol; methathesis ring-opening polymerization PROMERUS, LLC (US) 2009-05-07 US disclosed
EP-2031007-A2 Norbornene-type polymers, compositions thereof and lithographic processes using such compositions Promerus LLC (US) 2009-03-04 EP disclosed
US-20080242810-A1 Use of a Combination Chain Transfer and Activating Agent to Control Molecular Weight and Optical Density of Pd Catalyzed Norbornene Polymers PROMERUS LLC (US) 2008-10-02 US disclosed
US-20080242810-A1 Use of a Combination Chain Transfer and Activating Agent to Control Molecular Weight and Optical Density of Pd Catalyzed Norbornene Polymers PROMERUS LLC (US) 2008-10-02 US disclosed
US-20070172762-A1 Photoresist composition for deep ultraviolet lithography DAMMEL RALPH R 2007-07-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118539-A1 forming diastereomeric mixture of norbornenecarbonitrile via Diels-Alder reaction, separating, converting to diastereomeric norbornenecarboxaldehyde, and norbornenecarboxylic acid and alcohol; methathesis ring-opening polymerization MMAB, ADH1C, OXER1 KDM4E 3566/4885POLB 480/4885ALOX15 518/4885
US-20100099906-A1 GENERATION OF ENDO- AND/OR EXO-NORBORNENECARBOXALDEHYDE AS AN INTERMEDIATE TO FUNCTIONALIZED NORBORNENES GNE, GALE, EXOSC5 KDM4E 2962/4885POLB 1419/4885ALOX15 1243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.