Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.42 |
| ▸ | TUBB | P07437 | 3/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367376 | 0.86 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL9368290 | 0.77 | ALDH1A1 (0.46) | MAOAMAOBKMT2AMEN1ALDH1A1 | |
| SCHEMBL1369420 | 0.76 | NAMPT (0.49) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL7838597 | 0.75 | PTGER2 (0.42) | PTGER2MAOAMAOBALOX15KMT2A | |
| SCHEMBL17425318 | 0.73 | HDAC8 (0.77) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL8951821 | 0.72 | SLC6A4 (0.51) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1366120 | 0.69 | HDAC3 (0.53) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL9200716 | 0.68 | PARP1 (0.42) | PTGER2ALOX15KMT2AALDH1A1KDM4E | |
| SCHEMBL9194995 | 0.68 | SIRT1 (0.49) | HDAC6HDAC1HDAC3MAPTP2RX4 | |
| SCHEMBL1366170 | 0.67 | HDAC6 (0.61) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343286-A1 | Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2011-07-13 | — | — | EP | disclosed |