Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.47 |
| ▸ | SMYD2 | Q9NRG4 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246294 | 0.87 | DRD2 (0.59) | DRD2DRD3DRD4ADRB1ADRB2 | |
| SCHEMBL13437595 | 0.87 | DRD2 (0.56) | DRD2DRD3DRD4ADRB1ADRB2 | |
| Hydrochloric Acid SCHEMBL1244917 | 0.86 | DRD2 (0.58) | DRD2DRD3DRD4ADRB1ADRB2 | |
| SCHEMBL12119317 | 0.85 | DRD2 (0.56) | DRD2DRD3DRD4ADRB1ADRB2 | |
| SCHEMBL9909663 | 0.83 | ADRB1 (0.52) | DRD2DRD3DRD4ADRB1ADRB2 | |
| Acetic Acid SCHEMBL28545033 | 0.81 | DRD2 (0.53) | DRD2DRD3DRD4ADRB1ADRB2 | |
| Hydrochloric Acid SCHEMBL4022568 | 0.79 | ADRB1 (0.55) | DRD2DRD3DRD4ADRB1ADRB2 | |
| SCHEMBL9909524 | 0.75 | DRD2 (0.58) | DRD2DRD3DRD4ADRB1ADRB2 | |
| SCHEMBL15643174 | 0.72 | ADRB2 (0.49) | ADRB1ADRB2SMYD2 | |
| SCHEMBL10215347 | 0.72 | ADRB1 (0.65) | DRD2DRD3DRD4ADRB1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476265-B2 | Compounds-801 | ASTRAZENECA AB (SE) | 2013-07-02 | — | — | US | disclosed |
| US-8455483-B2 | Compounds—801 | ASTRAZENECA AB (SE) | 2013-06-04 | — | — | US | disclosed |
| US-20130018037-A1 | Compounds - 801 | ASTRAZENECA UK LIMITED (GB) | 2013-01-17 | — | — | US | disclosed |
| EP-2459572-A2 | SPIROCYCLIC AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2012-06-06 | — | — | EP | disclosed |
| US-20110053909-A1 | Compounds - 801 | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2011-03-03 | — | — | US | disclosed |
| WO-2011012896-A2 | COMPOUNDS - 801 | ASTRAZENECA AB (SE) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018037-A1 | Compounds - 801 | ADRA2C, ADRB2, ADRB1 | DRD2 139/4885DRD3 268/4885DRD4 447/4885 |
| US-20110053909-A1 | Compounds - 801 | ADRA2C, ADRB2, ADRB1 | DRD2 139/4885DRD3 268/4885DRD4 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.