Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PTPRF | P10586 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPRA | P18433 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12464228 | 0.88 | MAPT (0.48) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12464230 | 0.83 | KDM4E (0.44) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4152021 | 0.81 | NR1I2 (0.34) | KDM4EHDAC6 | |
| SCHEMBL2157819 | 0.81 | NR1I2 (0.34) | KDM4EHDAC6 | |
| SCHEMBL2157771 | 0.78 | FLT1 (0.40) | MAPTSMN1; SMN2PTPN1PTPRAALDH1A1 | |
| SCHEMBL14048971 | 0.76 | PTPN1 (0.47) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2157772 | 0.75 | IKBKB (0.46) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27592383 | 0.75 | ALDH1A1 (0.43) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2249001 | 0.74 | KDM4E (0.47) | KDM4EMAPTPTPN1IKBKBMEN1 | |
| SCHEMBL14048991 | 0.74 | TRPM8 (0.46) | MAPTPTPRFPTPN1PTPRAIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985769-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |