Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12464228 | 0.92 | MAPT (0.48) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL12464523 | 0.88 | HSD17B1 (0.44) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL2511421 | 0.83 | HSD17B1 (0.45) | KDM4ENPC1MAPTRAB9AHSD17B1 | |
| SCHEMBL12464388 | 0.83 | KDM4E (0.38) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL13270830 | 0.81 | HSD17B1 (0.39) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL2157604 | 0.81 | HSD17B1 (0.39) | KDM4ENPC1MAPTRAB9AHSD17B1 | |
| SCHEMBL2158728 | 0.81 | HSD17B1 (0.43) | KDM4ENPC1MAPTRAB9AHSD17B1 | |
| SCHEMBL14048991 | 0.80 | TRPM8 (0.46) | MAPTMEN1KMT2APOLB | |
| SCHEMBL27592383 | 0.79 | ALDH1A1 (0.43) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL2157757 | 0.78 | HSD17B1 (0.41) | HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985769-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |