Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.40 |
| ▸ | FABP1 | P07148 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245176 | 0.96 | NR1H4 (0.40) | NR1H4LPAR1LPAR2LPAR3FABP1 | |
| SCHEMBL1246477 | 0.95 | NR1H4 (0.42) | NR1H4FABP1FABP4GPBAR1PPARD | |
| SCHEMBL1246467 | 0.95 | NR1H4 (0.43) | NR1H4LPAR1LPAR2LPAR3FABP1 | |
| SCHEMBL1246476 | 0.94 | NR1H4 (0.42) | NR1H4LPAR1LPAR2LPAR3FABP1 | |
| SCHEMBL1245335 | 0.92 | NR1H4 (0.50) | NR1H4FABP1FABP4PPARDMAPT | |
| SCHEMBL1246307 | 0.92 | NR1H4 (0.44) | NR1H4GPBAR1PPARDMAPTSCN9A | |
| SCHEMBL1247211 | 0.91 | FFAR4 (0.42) | NR1H4FABP1GPBAR1PPARDMAPT | |
| SCHEMBL1246442 | 0.91 | ALDH1A1 (0.39) | GPBAR1MAPTALDH1A1HPGDCYP2C19 | |
| SCHEMBL1247804 | 0.91 | NPSR1 (0.37) | NR1H4LPAR1LPAR2LPAR3GPBAR1 | |
| SCHEMBL1247748 | 0.90 | SCN9A (0.39) | NR1H4FABP1FABP4GPBAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | disclosed |