Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247806 | 0.93 | GPBAR1 (0.43) | GPBAR1MAPTHPGDALDH1A1POLB | |
| SCHEMBL1247124 | 0.87 | NR1H4 (0.43) | GPBAR1MAPTHPGDALDH1A1POLB | |
| SCHEMBL3711309 | 0.87 | FTO (0.36) | GPBAR1HPGDALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1246421 | 0.86 | SCN9A (0.39) | GPBAR1MAPTHPGDALDH1A1POLB | |
| SCHEMBL1245320 | 0.84 | NR1H4 (0.45) | GPBAR1MAPTHPGDALDH1A1POLB | |
| SCHEMBL1247757 | 0.83 | NR1H4 (0.38) | GPBAR1MAPTHPGDALDH1A1POLB | |
| SCHEMBL1246467 | 0.83 | NR1H4 (0.43) | GPBAR1 | |
| SCHEMBL1247108 | 0.82 | SCN9A (0.40) | GPBAR1 | |
| SCHEMBL1247564 | 0.82 | MAPT (0.42) | GPBAR1MAPTHPGDALDH1A1POLB | |
| SCHEMBL1246290 | 0.82 | SCN9A (0.40) | GPBAR1MAPTHPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |