Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245320 | 0.92 | NR1H4 (0.45) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1247097 | 0.90 | GABRA5 (0.44) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1245358 | 0.89 | NR1H4 (0.42) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1247222 | 0.88 | ALDH1A1 (0.36) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1247124 | 0.88 | NR1H4 (0.43) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1247806 | 0.88 | GPBAR1 (0.43) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1246422 | 0.88 | KMO (0.41) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1247211 | 0.87 | FFAR4 (0.42) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1245152 | 0.87 | NR1H4 (0.42) | MAPTALDH1A1POLBHPGDGPBAR1 | |
| SCHEMBL1245116 | 0.87 | PTGS2 (0.39) | MAPTALDH1A1POLBHPGDGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |