Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.45 |
| ▸ | LIFR | P42702 | 1/20 | 0.45 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247124 | 0.96 | NR1H4 (0.43) | NR1H4LIFRHSD17B13MAPTALDH1A1 | |
| SCHEMBL1247564 | 0.92 | MAPT (0.42) | NR1H4MAPTALDH1A1POLBHPGD | |
| SCHEMBL1246239 | 0.90 | MAPT (0.39) | NR1H4LIFRMAPTALDH1A1POLB | |
| SCHEMBL1246422 | 0.89 | KMO (0.41) | NR1H4LIFRMAPTALDH1A1POLB | |
| SCHEMBL1246307 | 0.88 | NR1H4 (0.44) | NR1H4MAPTPTGS2TSHRGPBAR1 | |
| SCHEMBL1245111 | 0.88 | NR1H4 (0.50) | NR1H4LIFRHPGDLMNATDP1 | |
| SCHEMBL1246467 | 0.87 | NR1H4 (0.43) | NR1H4PTGS2GPBAR1SCN9A | |
| SCHEMBL1246421 | 0.86 | SCN9A (0.39) | MAPTALDH1A1POLBHPGDLMNA | |
| SCHEMBL2336147 | 0.86 | NR1H4 (0.42) | NR1H4LIFRHSD17B13LMNAGAA | |
| SCHEMBL1247222 | 0.85 | ALDH1A1 (0.36) | MAPTALDH1A1POLBHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |