Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 6/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.37 |
| ▸ | HNF4A | P41235 | 2/20 | 0.35 |
| ▸ | RARA | P10276 | 4/20 | 0.34 |
| ▸ | RARB | P10826 | 4/20 | 0.34 |
| ▸ | RARG | P13631 | 4/20 | 0.34 |
| ▸ | RXRA | P19793 | 4/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | RXRG | P48443 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7196167 | 0.81 | PTGS1 (0.34) | SSTR5PTGS1PTGS2CYP26A1CYP26B1 | |
| SCHEMBL7183938 | 0.79 | HNF4A (0.44) | SSTR5PTGS1PTGS2CYP26A1CYP26B1 | |
| SCHEMBL7196169 | 0.77 | PTGS1 (0.42) | SSTR5PTGS1PTGS2CYP26A1CYP26B1 | |
| SCHEMBL11241526 | 0.67 | RXRA (0.60) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL6146899 | 0.66 | CYP26A1 (0.69) | SSTR5CYP26A1CYP26B1HNF4ARARA | |
| SCHEMBL2053058 | 0.65 | CYP26A1 (0.46) | SSTR5CYP26A1CYP26B1HNF4ARARA | |
| SCHEMBL12182489 | 0.64 | PTGS1 (0.41) | SSTR5PTGS1PTGS2CYP26A1CYP26B1 | |
| SCHEMBL15002369 | 0.63 | PTGS1 (0.35) | SSTR5PTGS1PTGS2CYP26A1CYP26B1 | |
| SCHEMBL3584479 | 0.62 | PTGS2 (0.62) | PTGS1PTGS2 | |
| SCHEMBL21911671 | 0.62 | PARP1 (0.54) | HNF4ARARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586460-B1 | Administering heterocyclic ethers or sulfides to induce apoptosis, cell differentiation and as anticarcinogenic agents | THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY | 2003-07-01 | — | — | US | disclosed |