Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COXFA4 | O00483 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
| ▸ | GNG2 | P59768 | 1/20 | 0.42 |
| ▸ | GNB1 | P62873 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | SI | P14410 | 5/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880185 | 0.82 | RXRA (0.64) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL6210627 | 0.82 | RXRA (0.50) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL30195971 | 0.82 | RXRA (0.64) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL30026892 | 0.82 | RXRA (0.50) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL3782343 | 0.81 | COXFA4 (0.49) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL18270705 | 0.81 | CTSB (0.46) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL4857018 | 0.81 | CTSB (0.46) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL12467526 | 0.80 | COXFA4 (0.42) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL26054454 | 0.79 | COXFA4 (0.47) | COXFA4CTSBRXRATDP1SSTR5 | |
| SCHEMBL16742142 | 0.79 | COXFA4 (0.53) | COXFA4CTSBRXRATDP1SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670744-B1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LTD (IN) | 2015-05-27 | — | — | EP | disclosed |
| EP-2670744-B1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LTD (IN) | 2015-05-27 | — | — | EP | disclosed |
| EP-2670744-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | Lupin Limited (IN) | 2013-12-11 | — | — | EP | disclosed |
| US-20130310419-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2013-11-21 | — | — | US | disclosed |
| US-20130310419-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2013-11-21 | — | — | US | disclosed |
| WO-2012104782-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310419-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | CHRNA7, CHRNE, CHRNA5 | COXFA4 3224/4885CTSB 2403/4885RXRA 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.