Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.64 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.51 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30195971 | 1.00 | RXRA (0.64) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL5712102 | 0.91 | RXRA (0.55) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL6210627 | 0.88 | RXRA (0.50) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL30026892 | 0.88 | RXRA (0.50) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL3782343 | 0.86 | COXFA4 (0.49) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL9850252 | 0.86 | RXRA (0.53) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL5311364 | 0.85 | RXRA (0.49) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL2812534 | 0.84 | RXRA (0.52) | RXRASSTR5TDP1MAPTALDH1A1 | |
| SCHEMBL26054454 | 0.84 | COXFA4 (0.47) | RXRASSTR5COXFA4TDP1MAPT | |
| SCHEMBL16742142 | 0.84 | COXFA4 (0.53) | RXRASSTR5COXFA4TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148292-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | UNIV EMORY (US) | 2015-05-28 | — | — | US | claimed |
| WO-2014011540-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-01-16 | — | — | WO | claimed |
| US-12492177-B2 | RAR-α compounds for inflammatory disease and male contraception | Orphagen Pharmaceuticals, Inc. (US) | 2025-12-09 | — | — | US | disclosed |
| US-20230357175-A1 | RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION | Orphagen Pharmaceuticals, Inc. | 2023-11-09 | — | — | US | disclosed |
| US-20230357175-A1 | RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION | Orphagen Pharmaceuticals, Inc. | 2023-11-09 | — | — | US | disclosed |
| US-20230357175-A1 | RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION | Orphagen Pharmaceuticals, Inc. | 2023-11-09 | — | — | US | disclosed |
| CN-115335367-A | RAR-alpha compounds for use in inflammatory diseases and male contraception | 奥弗恩制药公司 | 2022-11-11 | — | — | CN | disclosed |
| EP-4077300-A1 | RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION | Orphagen Pharmaceuticals, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127250-A1 | RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION | Orphagen Pharmaceuticals, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127250-A1 | RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION | Orphagen Pharmaceuticals, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| EP-0991636-B1 | SYNTHESIS AND USE OF RETINOID COMPOUNDS HAVING NEGATIVE HORMONE AND/OR ANTAGONIST ACTIVITIES | ALLERGAN INC (US) | 2005-03-02 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| EP-0991636-A1 | SYNTHESIS AND USE OF RETINOID COMPOUNDS HAVING NEGATIVE HORMONE AND/OR ANTAGONIST ACTIVITIES | Allergan Sales, Inc. (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |
| US-5877207-A | SKIN DISORDERS; ANTICARCINOGENIC AGENTS | ALLERGAN SALES, INC. (US) | 1999-03-02 | — | — | US | disclosed |
| WO-1998058922-A1 | SYNTHESIS AND USE OF RETINOID COMPOUNDS HAVING NEGATIVE HORMONE AND/OR ANTAGONIST ACTIVITIES | ALLERGAN SALES, INC. (US) | 1998-12-30 | — | — | WO | disclosed |
| EP-0435681-A1 | Chroman esters of phenols and benzoic acids having retinoid-like activity | ALLERGAN, INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5006550-A | Skin disorder, arthritis, wound healing agents, dry eye syndrome | ALLERGAN, INC. (US) | 1991-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357175-A1 | RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION | RARA, RARB, RARG | RXRA 4/4885SSTR5 3496/4885COXFA4 2212/4885 |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | RXRA 3691/4885SSTR5 4556/4885COXFA4 4806/4885 |
| US-20150148292-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | BMP4, BMP2, BMP1 | RXRA 773/4885SSTR5 3345/4885COXFA4 945/4885 |
| US-12492177-B2 | RAR-α compounds for inflammatory disease and male contraception | RARA, RARB, RARG | RXRA 4/4885SSTR5 3496/4885COXFA4 2177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.