Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889429 | 0.78 | LMNA (0.51) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL11889474 | 0.74 | LMNA (0.46) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5222008 | 0.74 | RAB9A (0.43) | SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL18209401 | 0.73 | TDP1 (0.66) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL10587435 | 0.69 | LMNA (0.55) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL11889228 | 0.68 | ALDH1A1 (0.53) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL19608995 | 0.67 | NPC1 (0.60) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL20563011 | 0.67 | LMNA (0.49) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL14825221 | 0.66 | NCEH1 (1.00) | NCEH1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL223575 | 0.66 | ALDH1A1 (0.42) | SMN1; SMN2NPC1RAB9APOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668160-A1 | TRPM8 RECEPTOR ANTAGONISTS | Dompe' S.p.A. (IT) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101244-A1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPE' S.P.A. (IT) | 2012-08-02 | — | — | WO | disclosed |