Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10587435 | 0.78 | LMNA (0.55) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL11889429 | 0.76 | LMNA (0.51) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL20563011 | 0.76 | LMNA (0.49) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL11889200 | 0.75 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL11889108 | 0.75 | NPBWR1 (0.41) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL11888990 | 0.75 | KMT2A (0.41) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL12466170 | 0.74 | NCEH1 (0.49) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL19608990 | 0.74 | GAA (0.61) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| Hydrochloric Acid SCHEMBL11889093 | 0.74 | HTR1B (0.62) | LMNASMN1; SMN2NCEH1NPC1GAA | |
| SCHEMBL16252788 | 0.73 | L3MBTL1 (0.46) | LMNASMN1; SMN2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668160-B1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPÉ FARMACEUTICI S P A (IT) | 2015-08-12 | — | — | EP | disclosed |
| US-8906946-B2 | TRPM8 receptor antagonists | DOMPE' S.P.A. (IT) | 2014-12-09 | — | — | US | disclosed |
| US-20140031398-A1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2014-01-30 | — | — | US | disclosed |
| EP-2668160-A1 | TRPM8 RECEPTOR ANTAGONISTS | Dompe' S.p.A. (IT) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101244-A1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPE' S.P.A. (IT) | 2012-08-02 | — | — | WO | disclosed |
| EP-2481727-A1 | TRPM8 receptor antagonists | Dompe S.p.A. (IT) | 2012-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031398-A1 | TRPM8 RECEPTOR ANTAGONISTS | TRPM8, TRPM6, TRPM7 | LMNA 3526/4885SMN1; SMN2 979/4885NCEH1 1555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.