Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466027 | 0.87 | ALDH1A1 (0.41) | ALDH1A1HTTLMNASMN1; SMN2HPGD | |
| SCHEMBL11888924 | 0.85 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL11890076 | 0.84 | NCEH1 (0.45) | NCEH1ALDH1A1HTTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11888948 | 0.84 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL14376152 | 0.72 | NCEH1 (0.52) | NCEH1ALDH1A1HTTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL12465902 | 0.72 | NCEH1 (0.49) | NCEH1ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL11888932 | 0.71 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL11959228 | 0.70 | HTR6 (0.48) | NCEH1ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL11889066 | 0.70 | LMNA (0.43) | NCEH1ALDH1A1LMNASMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL11889140 | 0.70 | HTR6 (0.48) | NCEH1ALDH1A1HTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668160-B1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPÉ FARMACEUTICI S P A (IT) | 2015-08-12 | — | — | EP | disclosed |
| US-8906946-B2 | TRPM8 receptor antagonists | DOMPE' S.P.A. (IT) | 2014-12-09 | — | — | US | disclosed |
| US-20140031398-A1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2014-01-30 | — | — | US | disclosed |
| EP-2668160-A1 | TRPM8 RECEPTOR ANTAGONISTS | Dompe' S.p.A. (IT) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012100748-A1 | GLP-1 RECEPTOR AGONIST FOR TREATING PAIN | WANG YONGXIANG (CN) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101244-A1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPE' S.P.A. (IT) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031398-A1 | TRPM8 RECEPTOR ANTAGONISTS | TRPM8, TRPM6, TRPM7 | NCEH1 1555/4885ALDH1A1 4725/4885HTT 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.