Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 3/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14943230 | 0.90 | HPGD (0.53) | HPGDALDH1A1LMNAFAAHTAS1R3 | |
| SCHEMBL12401688 | 0.87 | HPGD (0.50) | HPGDALDH1A1LMNAFAAHTAS1R3 | |
| SCHEMBL179087 | 0.79 | LMNA (0.60) | ALDH1A1LMNAFAAHRAB9AKDM4E | |
| SCHEMBL5191013 | 0.75 | ALDH1A1 (0.60) | HPGDALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL11744707 | 0.74 | HSD17B10 (0.70) | HPGDALDH1A1LMNAFAAHPOLB | |
| SCHEMBL31557713 | 0.74 | TAS1R3 (0.61) | HPGDALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL2746737 | 0.73 | POLB (0.53) | HPGDALDH1A1LMNAFAAHPOLB | |
| SCHEMBL30544976 | 0.73 | ALDH1A1 (0.62) | ALDH1A1LMNAFAAHRAB9AKDM4E | |
| SCHEMBL2730357 | 0.73 | ALDH1A1 (0.62) | ALDH1A1LMNAFAAHRAB9AKDM4E | |
| SCHEMBL29673912 | 0.73 | ALDH1A1 (0.57) | HPGDALDH1A1LMNAFAAHPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |