Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635836 | 0.78 | CDC7 (0.61) | TBK1CDC7CCNE1CDK2DBF4 | |
| SCHEMBL14059455 | 0.78 | TBK1 (0.50) | TBK1CDC7CCNE1CDK2DBF4 | |
| SCHEMBL9823522 | 0.76 | RAB9A (0.55) | TBK1SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL30511202 | 0.75 | CDC7 (0.58) | TBK1CDC7CCNE1CDK2DBF4 | |
| SCHEMBL12009456 | 0.74 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1ALDH1A1MAPTGAA | |
| SCHEMBL14275905 | 0.74 | CYP1A1 (0.49) | CDC7CCNE1CDK2DBF4L3MBTL1 | |
| SCHEMBL15650922 | 0.72 | MAPK1 (0.32) | TBK1IKBKEIKBKB | |
| SCHEMBL15652654 | 0.72 | COPS5 (0.44) | SMN1; SMN2L3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL6628198 | 0.72 | CDC7 (0.62) | TBK1CDC7CCNE1CDK2DBF4 | |
| SCHEMBL7456488 | 0.71 | ALDH1A1 (0.65) | TBK1CDC7CCNE1CDK2DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278969-A2 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2010011375-A2 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2010-01-28 | — | — | WO | disclosed |