Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | UGT2B7 | P16662 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10990788 | 0.88 | UGT2B7 (0.45) | TSHRLMNAPOLBALDH1A1UGT2B7 | |
| SCHEMBL5682017 | 0.83 | CYP2D6 (0.47) | TSHRLMNAALDH1A1UGT2B7CYP2D6 | |
| SCHEMBL13681637 | 0.83 | CYP2D6 (0.47) | TSHRLMNAALDH1A1UGT2B7CYP2D6 | |
| SCHEMBL7040044 | 0.78 | UGT2B7 (0.39) | TSHRLMNAALDH1A1UGT2B7CYP2D6 | |
| SCHEMBL7040043 | 0.78 | UGT2B7 (0.39) | TSHRLMNAALDH1A1UGT2B7CYP2D6 | |
| SCHEMBL8948028 | 0.77 | PIK3CD (0.40) | ALDH1A1TDP1 | |
| SCHEMBL24869876 | 0.75 | ALDH1A1 (0.59) | TSHRLMNAPOLBALDH1A1RAB9A | |
| SCHEMBL22952773 | 0.75 | UGT2B7 (0.44) | TSHRALDH1A1UGT2B7CYP2D6L3MBTL1 | |
| SCHEMBL31555479 | 0.75 | GAA (0.47) | TSHRALDH1A1UGT2B7CYP2D6L3MBTL1 | |
| SCHEMBL31547177 | 0.74 | ALDH1A1 (0.47) | TSHRLMNAPOLBALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627654-A1 | METHOD OF MAKING AZAINDAZOLE DERIVATIVES | Takeda California, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| US-20130197229-A1 | METHOD OF MAKING AZAINDAZOLE DERIVATIVES | TAKEDA CALIFORNIA, INC. | 2013-08-01 | — | — | US | disclosed |
| US-20130197229-A1 | METHOD OF MAKING AZAINDAZOLE DERIVATIVES | TAKEDA CALIFORNIA, INC. | 2013-08-01 | — | — | US | disclosed |
| US-20130197229-A1 | METHOD OF MAKING AZAINDAZOLE DERIVATIVES | TAKEDA CALIFORNIA, INC. | 2013-08-01 | — | — | US | disclosed |
| WO-2012051450-A1 | METHOD OF MAKING AZAINDAZOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130197229-A1 | METHOD OF MAKING AZAINDAZOLE DERIVATIVES | GCK, GALK1, GCKR | TSHR 3278/4885LMNA 4377/4885POLB 3341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.