Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469198 | 0.83 | FFAR2 (0.39) | MAPTGAAPIK3CALMNAFFAR2 | |
| SCHEMBL11972849 | 0.82 | PDE3B (0.46) | MAPTGAAPIK3CALMNAPRKDC | |
| SCHEMBL11997711 | 0.81 | DGAT1 (0.40) | MAPTGAAPIK3CALMNAFFAR2 | |
| SCHEMBL12469236 | 0.76 | LMNA (0.41) | MAPTGAAPIK3CALMNAEGFR | |
| SCHEMBL11973421 | 0.73 | FFAR2 (0.39) | MAPTGAALMNAFFAR2DGAT1 | |
| SCHEMBL627395 | 0.72 | PIK3CA (0.47) | MAPTGAAPIK3CALMNAEGFR | |
| SCHEMBL626844 | 0.71 | PIK3CA (0.44) | MAPTGAAPIK3CALMNADGAT1 | |
| SCHEMBL11997712 | 0.70 | ADORA1 (0.35) | MAPTGAAPIK3CALMNAFFAR2 | |
| SCHEMBL16849913 | 0.66 | FFAR2 (0.46) | MAPTPIK3CALMNAFFAR2PRKDC | |
| SCHEMBL624286 | 0.66 | MAPT (0.48) | MAPTGAAPIK3CALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627181-A2 | HETEROARYLS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051410-A2 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-19 | — | — | WO | disclosed |