Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11972849 | 0.79 | PDE3B (0.46) | LMNARAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL12469238 | 0.76 | MAPT (0.39) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL627395 | 0.71 | PIK3CA (0.47) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12469198 | 0.69 | FFAR2 (0.39) | LMNAKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL624070 | 0.67 | PIK3CD (0.45) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL623813 | 0.67 | EGFR (0.43) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11997711 | 0.67 | DGAT1 (0.40) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL626111 | 0.65 | PIK3CD (0.47) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL3103188 | 0.65 | CASP7 (0.48) | LMNARAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL3121764 | 0.65 | ALDH1A1 (0.57) | LMNARAB9AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627181-A2 | HETEROARYLS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051410-A2 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-19 | — | — | WO | disclosed |