Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 10/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708656 | 0.80 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL1283007 | 0.80 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL1282966 | 0.79 | ABL1 (0.56) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL1292161 | 0.76 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL28805227 | 0.75 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL12469561 | 0.75 | NPC1 (0.32) | NPC1 | |
| SCHEMBL12469595 | 0.75 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL1708003 | 0.72 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL220748 | 0.71 | ABL1 (0.52) | ABL1 | |
| SCHEMBL1282103 | 0.71 | ABL1 (0.43) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | claimed |
| EP-2625178-A1 | BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS | Biota Europe Ltd (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012045124-A1 | BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS | BIOTA EUROPE LTD (GB) | 2012-04-12 | — | — | WO | disclosed |