Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 16/20 | 0.72 |
| ▸ | LATS1 | O95835 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704222 | 0.84 | KARS1 (1.00) | KARS1 | |
| SCHEMBL901738 | 0.81 | KARS1 (0.58) | KARS1 | |
| SCHEMBL901688 | 0.81 | KARS1 (0.48) | KARS1LATS1ROCK2ROCK1 | |
| SCHEMBL901752 | 0.73 | KARS1 (0.73) | KARS1 | |
| SCHEMBL12469310 | 0.73 | KARS1 (0.56) | KARS1 | |
| SCHEMBL1755643 | 0.73 | KARS1 (1.00) | KARS1 | |
| SCHEMBL10268986 | 0.72 | KARS1 (0.75) | KARS1 | |
| SCHEMBL902386 | 0.72 | KARS1 (0.75) | KARS1 | |
| SCHEMBL1755689 | 0.72 | KARS1 (0.75) | KARS1 | |
| SCHEMBL902170 | 0.72 | KARS1 (0.77) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |