Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 8/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.66 |
| ▸ | FLT1 | P17948 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.66 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.65 |
| ▸ | NEK2 | P51955 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | TLK2 | Q86UE8 | 5/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473995 | 1.00 | PAK4 (0.78) | PAK4HDAC3PDGFRBFLT1KDR | |
| SCHEMBL24667 | 0.90 | PAK4 (0.75) | PAK4HDAC3PDGFRBFLT1KDR | |
| SCHEMBL25738 | 0.87 | PAK4 (0.77) | PAK4CDK1CCNB1NEK2TLK2 | |
| SCHEMBL5368518 | 0.82 | PAK4 (0.75) | PAK4CDK1CCNB1NEK2TLK2 | |
| SCHEMBL20937 | 0.80 | PAK4 (0.71) | PAK4CDK1CCNB1NEK2TLK2 | |
| SCHEMBL21115 | 0.79 | HDAC3 (1.00) | HDAC3PDGFRBFLT1KDRHDAC4 | |
| SCHEMBL21116 | 0.79 | HDAC3 (1.00) | HDAC3PDGFRBFLT1KDRHDAC4 | |
| SCHEMBL12200908 | 0.79 | NEK2 (1.00) | PAK4PDGFRBFLT1KDRCDK1 | |
| SCHEMBL31061298 | 0.79 | NEK2 (1.00) | PAK4PDGFRBFLT1KDRCDK1 | |
| SCHEMBL20944 | 0.79 | TLK2 (1.00) | PAK4PDGFRBFLT1KDRCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | claimed |
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | disclosed |