Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12484150 | 0.98 | TSHR (0.47) | TSHRPTPN7KMT2ARECQLMEN1 | |
| SCHEMBL12484913 | 0.98 | TSHR (0.47) | TSHRPTPN7KMT2ARECQLMEN1 | |
| SCHEMBL9975552 | 0.95 | TSHR (0.50) | TSHRPTPN7KMT2ARECQLMEN1 | |
| SCHEMBL9975548 | 0.95 | TSHR (0.50) | TSHRPTPN7KMT2ARECQLMEN1 | |
| SCHEMBL6744982 | 0.95 | TSHR (0.50) | TSHRPTPN7KMT2ARECQLMEN1 | |
| SCHEMBL12910845 | 0.93 | TSHR (0.52) | TSHRPTPN7KMT2ARECQLALDH1A1 | |
| SCHEMBL2481274 | 0.93 | TSHR (0.52) | TSHRPTPN7KMT2ARECQLALDH1A1 | |
| SCHEMBL12484178 | 0.89 | TSHR (0.48) | TSHRPTPN7KMT2ARECQLMEN1 | |
| SCHEMBL12486211 | 0.89 | TSHR (0.48) | TSHRPTPN7KMT2ARECQLMEN1 | |
| SCHEMBL659218 | 0.89 | TSHR (0.56) | TSHRPTPN7KMT2ARECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150266847-A1 | MACROCYCLIC TRIENE LACTONES HAVING UNCONJUGATED TRIENE STRUCTURE, ITS PRODUCTION METHOD AND ITS SYNTHETIC INTERMEDIATE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2015-09-24 | — | — | US | disclosed |
| US-9085545-B2 | Macrocyclic triene lactones having unconjugated triene structure, its production method and its synthetic intermediate | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2015-07-21 | — | — | US | disclosed |
| US-20130324744-A1 | MACROCYCLIC TRIENE LACTONES HAVING UNCONJUGATED TRIENE STRUCTURE, ITS PRODUCTION METHOD AND ITS SYNTHETIC INTERMEDIATE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-12-05 | — | — | US | disclosed |
| WO-2012115285-A1 | MACROCYCLIC TRIENE LACTONES HAVING UNCONJUGATED TRIENE STRUCTURE, ITS PRODUCTION METHOD AND ITS SYNTHETIC INTERMEDIATE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130324744-A1 | MACROCYCLIC TRIENE LACTONES HAVING UNCONJUGATED TRIENE STRUCTURE, ITS PRODUCTION METHOD AND ITS SYNTHETIC INTERMEDIATE | TAS2R13, TAS2R40, TAS2R14 | TSHR 1887/4885PTPN7 4260/4885KMT2A 3074/4885 |
| US-20150266847-A1 | MACROCYCLIC TRIENE LACTONES HAVING UNCONJUGATED TRIENE STRUCTURE, ITS PRODUCTION METHOD AND ITS SYNTHETIC INTERMEDIATE | TAS2R13, TAS2R40, TAS2R14 | TSHR 1887/4885PTPN7 4260/4885KMT2A 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.