Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9975552 | 0.94 | TSHR (0.50) | TSHRLMNAALDH1A1PPARGPPARA | |
| SCHEMBL6744982 | 0.94 | TSHR (0.50) | TSHRLMNAALDH1A1PPARGPPARA | |
| SCHEMBL9975548 | 0.94 | TSHR (0.50) | TSHRLMNAALDH1A1PPARGPPARA | |
| SCHEMBL12910845 | 0.92 | TSHR (0.52) | TSHRLMNAALDH1A1KMT2ARECQL | |
| SCHEMBL2481274 | 0.92 | TSHR (0.52) | TSHRLMNAALDH1A1KMT2ARECQL | |
| SCHEMBL12484115 | 0.89 | TSHR (0.48) | TSHRLMNAALDH1A1PPARGPPARA | |
| SCHEMBL7551344 | 0.88 | TSHR (0.56) | TSHRLMNAALDH1A1PPARGPPARA | |
| SCHEMBL12484913 | 0.87 | TSHR (0.47) | TSHRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL12484150 | 0.87 | TSHR (0.47) | TSHRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL14198597 | 0.84 | TSHR (0.52) | TSHRLMNAALDH1A1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663305-B1 | METHOD FOR INTRODUCING SUBSTITUENTS INTO ALPHA,BETA-UNSATURATED KETONE AND PROSTAGLANDIN COMPOUND SYNTHESIS METHOD UTILIZING SAME | NAT CT GERIATRICS & GERONTOLOGY (JP) | 2023-08-30 | — | — | EP | disclosed |
| US-11384044-B2 | Method for introducing substituent into α,β-unsaturated ketone and method for synthesizing prostaglandin using the same | NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY (JP) | 2022-07-12 | — | — | US | disclosed |
| US-20210355061-A1 | METHOD FOR INTRODUCING SUBSTITUENT INTO alpha,beta-UNSATURATED KETONE AND METHOD FOR SYNTHESIZING PROSTAGLANDIN USING THE SAME | NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY (JP) | 2021-11-18 | — | — | US | disclosed |
| EP-3663305-A1 | METHOD FOR INTRODUCING SUBSTITUENTS INTO , -UNSATURATED KETONE AND PROSTAGLANDIN COMPOUND SYNTHESIS METHOD UTILIZING SAME | National Center for Geriatrics and Gerontology (JP) | 2020-06-10 | — | — | EP | disclosed |
| EP-2803358-B1 | 10,10-Dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure | ALLERGAN INC (US) | 2017-05-03 | — | — | EP | disclosed |
| US-9637467-B2 | Treatment of inflammatory bowel disease | ALLERGAN, INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9637467-B2 | Treatment of inflammatory bowel disease | ALLERGAN, INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9334262-B2 | Methods of treating soft tissue defects | ALLERGAN, INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20160096817-A1 | TREATMENT OF INFLAMMATORY BOWEL DISEASE | ALLERGAN, INC. | 2016-04-07 | — | — | US | disclosed |
| US-20160096817-A1 | TREATMENT OF INFLAMMATORY BOWEL DISEASE | ALLERGAN, INC. | 2016-04-07 | — | — | US | disclosed |
| US-20040157901-A1 | 10,10-DIALKYL PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6333441-B1 | FORMING MIXTURE COMPRISING FORMIC ACID, TRIETHYLAMINE, TRIBUTYLPHOSPHINE, AND TRIS(DIBENZYLIDENEACETONE) DIPALLADIUM (0)-CHLOROFORM ADDUCT IN SOLVENT, ADDING THERETO ALKYNE UNDER EFFECTIVE REDUCTION CONDITIONS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1075464-A1 | NOVEL PROCESS | AstraZeneca Aktiebolag (SE) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999044990-A1 | NOVEL PROCESS | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |
| EP-0560532-B1 | Preparation of cis-olefins | NISSAN CHEMICAL IND LTD (JP) | 1999-08-04 | — | — | EP | disclosed |
| EP-0560532-A1 | Preparation of cis-olefins | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1993-09-15 | — | — | EP | disclosed |
| US-4873360-A | Process for the preparation of cyclopentanoids and novel intermediates produced thereby | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1989-10-10 | — | — | US | disclosed |
| US-4234720-A | Prostaglandin derivatives | ABBOTT LABORATORIES (US) | 1980-11-18 | — | — | US | disclosed |
| US-4188331-A | Prostaglandin derivatives | ABBOTT LABORATORIES (US) | 1980-02-12 | — | — | US | disclosed |
| US-4117014-A | PROSTAGLANDIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1978-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096817-A1 | TREATMENT OF INFLAMMATORY BOWEL DISEASE | SLC10A2, FABP2, LTB4R2 | TSHR 1597/4885LMNA 2243/4885ALDH1A1 1092/4885 |
| US-20210355061-A1 | METHOD FOR INTRODUCING SUBSTITUENT INTO alpha,beta-UNSATURATED KETONE AND METHOD FOR SYNTHESIZING PROSTAGLANDIN USING THE SAME | PTGES, PTGES2, PTGES3 | TSHR 1139/4885LMNA 1021/4885ALDH1A1 677/4885 |
| US-20040157901-A1 | 10,10-DIALKYL PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE | PTGIR, CBR1, DECR1 | TSHR 144/4885LMNA 1100/4885ALDH1A1 2073/4885 |
| US-11384044-B2 | Method for introducing substituent into α,β-unsaturated ketone and method for synthesizing prostaglandin using the same | PTGES, PTGES2, PTGES3 | TSHR 1094/4885LMNA 991/4885ALDH1A1 618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.