Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.69 |
| ▸ | ECE1 | P42892 | 2/20 | 0.69 |
| ▸ | MUS81 | Q96NY9 | 2/20 | 0.69 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | AR | P10275 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486367 | 1.00 | ECE2 (0.69) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL4570234 | 0.88 | DNM1 (0.78) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL4570238 | 0.85 | AR (0.75) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL5149469 | 0.85 | L3MBTL1 (0.82) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL8925781 | 0.85 | L3MBTL1 (0.82) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL6635439 | 0.85 | L3MBTL1 (0.82) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL1669454 | 0.85 | SIRT1 (0.74) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL3624710 | 0.85 | SIRT1 (0.74) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL31264820 | 0.84 | AR (0.69) | ECE2ECE1MUS81DNM1L3MBTL1 | |
| SCHEMBL684072 | 0.84 | AR (0.69) | ECE2ECE1MUS81DNM1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12377194-B2 | JAB1 inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2025-08-05 | — | — | US | disclosed |
| US-20220023506-A1 | JAB1 Inhibitory Compositions for Ossification and Methods Related Thereto | EMORY UNIVERSITY | 2022-01-27 | — | — | US | disclosed |
| US-11179500-B2 | JAB1 inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2021-11-23 | — | — | US | disclosed |
| EP-2678052-B1 | JAB1 BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | UNIV EMORY (US) | 2018-09-26 | — | — | EP | disclosed |
| US-20130344165-A1 | JAB1 INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-12-26 | — | — | US | disclosed |
| WO-2012116137-A2 | JAB1 BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-08-30 | — | — | WO | disclosed |