SCHEMBL684072

SCHEMBL684072

O=C(N/N=C/c1cc(Cl)cc(Cl)c1O)c1cc2ccccc2cc1O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.69
PIK3CG P48736 1/20 0.68
ECE2 P0DPD6 2/20 0.66
ECE1 P42892 2/20 0.66
MUS81 Q96NY9 2/20 0.66
SIRT1 Q96EB6 1/20 0.66
FTO Q9C0B1 1/20 0.66
PGR P06401 1/20 0.61
MEN1 O00255 7/20 0.59
KMT2A Q03164 7/20 0.59
KDM4E B2RXH2 3/20 0.59
L3MBTL1 Q9Y468 2/20 0.59
NPC1 O15118 2/20 0.59
TDP1 Q9NUW8 2/20 0.59
USP2 O75604 1/20 0.59
MCOLN3 Q8TDD5 1/20 0.59
DNM1 Q05193 2/20 0.58
MAPT P10636 3/20 0.55
GAA P10253 1/20 0.55
RECQL P46063 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31264820 1.00 AR (0.69) ARPIK3CGECE2ECE1MUS81
SCHEMBL14983737 0.87 AR (0.70) ARECE2ECE1MUS81SIRT1
SCHEMBL14976907 0.87 AR (0.70) ARECE2ECE1MUS81SIRT1
SCHEMBL14976908 0.87 AR (0.70) ARECE2ECE1MUS81SIRT1
SCHEMBL683738 0.86 PIK3CG (0.72) PIK3CGMEN1KMT2AKDM4EL3MBTL1
SCHEMBL1639164 0.86 PIK3CG (0.72) PIK3CGMEN1KMT2AKDM4EL3MBTL1
SCHEMBL1639165 0.86 PIK3CG (0.72) PIK3CGMEN1KMT2AKDM4EL3MBTL1
SCHEMBL14907026 0.86 PIK3CG (0.72) ARPIK3CGECE2ECE1MUS81
SCHEMBL16271255 0.85 DNM1 (0.64) ARPIK3CGECE2ECE1MUS81
SCHEMBL14983765 0.85 AR (0.76) ARPIK3CGECE2ECE1MUS81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 AR 2839/4885PIK3CG 2876/4885ECE2 1677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.