Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.67 |
| ▸ | PHLPP2 | Q6ZVD8 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 5/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | ATIC | P31939 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486710 | 1.00 | RPS6KA3 (0.67) | RPS6KA3PHLPP2POLBCYP2D6MAPT | |
| SCHEMBL8844924 | 0.83 | RPS6KA3 (0.64) | RPS6KA3PHLPP2POLBCYP2D6MAPT | |
| SCHEMBL8844931 | 0.83 | RPS6KA3 (0.64) | RPS6KA3PHLPP2POLBCYP2D6MAPT | |
| SCHEMBL8843743 | 0.82 | PHLPP2 (0.75) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL8843749 | 0.82 | PHLPP2 (0.75) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL12486691 | 0.82 | RPS6KA3 (0.62) | RPS6KA3PHLPP2POLBCYP2D6MAPT | |
| SCHEMBL12486693 | 0.82 | RPS6KA3 (0.62) | RPS6KA3PHLPP2POLBCYP2D6MAPT | |
| SCHEMBL9711553 | 0.80 | RPS6KA3 (1.00) | RPS6KA3PHLPP2POLBCYP2D6MAPT | |
| SCHEMBL7521259 | 0.78 | RPS6KA3 (0.58) | RPS6KA3PHLPP2POLBCYP2D6MAPT | |
| SCHEMBL7534490 | 0.78 | RPS6KA3 (0.58) | RPS6KA3PHLPP2POLBCYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-06 | — | — | US | disclosed |
| EP-2677865-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | Icahn School of Medicine at Mount Sinai (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012116170-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ZHOU MING-MING (US) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | NFKBIA, NFKB2, IKBKG | RPS6KA3 1654/4885PHLPP2 1158/4885POLB 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.