Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 7/20 | 0.44 |
| ▸ | F2 | P00734 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.40 |
| ▸ | MICA | Q29983 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MTTP | P55157 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16973973 | 1.00 | F10 (0.44) | F10F2PRSS1KCNA3CXCR1 | |
| SCHEMBL17764976 | 1.00 | F10 (0.44) | F10F2PRSS1KCNA3CXCR1 | |
| SCHEMBL27978387 | 1.00 | F10 (0.44) | F10F2PRSS1KCNA3CXCR1 | |
| SCHEMBL21315830 | 1.00 | F10 (0.44) | F10F2PRSS1KCNA3CXCR1 | |
| SCHEMBL29395657 | 0.87 | KCNH2 (0.51) | F10F2PRSS1CYP2D6OPRK1 | |
| SCHEMBL21575680 | 0.86 | CYP2D6 (0.44) | F10KCNA3CXCR1CXCR2CYP2D6 | |
| SCHEMBL18368294 | 0.85 | KDM4E (0.48) | F10F2PRSS1CYP2D6OPRK1 | |
| SCHEMBL17883715 | 0.83 | CTSS (0.49) | F10F2PRSS1CYP2D6CYP3A4 | |
| SCHEMBL16419148 | 0.82 | CTSK (0.52) | F10F2PRSS1CYP2D6OPRK1 | |
| SCHEMBL10084036 | 0.82 | CTSK (0.52) | F10F2PRSS1CYP2D6OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104133010-B | High performance liquid chromatography separation analysis Asimadoline intermediate and optical isomer | 北京万全德众医药生物技术有限公司 | 2019-11-29 | — | — | CN | disclosed |
| US-10131655-B2 | Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists | DR. REDDY'S LABORATORIES, LTD. (IN) | 2018-11-20 | — | — | US | disclosed |
| EP-2822928-B1 | SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS | Dr Reddys Laboratories Ltd (IN) | 2018-11-14 | — | — | EP | disclosed |
| US-20170001998-A1 | SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2017-01-05 | — | — | US | disclosed |
| EP-3097093-A1 | NOVEL HETEROBICYCLIC COMPOUNDS AS KAPPA OPIOID AGONISTS | Cadila Healthcare Limited (IN) | 2016-11-30 | — | — | EP | disclosed |
| US-9487510-B2 | Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-11-08 | — | — | US | disclosed |
| US-9303027-B2 | Kappa opioid receptor agonists | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-04-05 | — | — | US | disclosed |
| WO-2015114660-A1 | NOVEL HETEROBICYCLIC COMPOUNDS AS KAPPA OPIOID AGONISTS | CADILA HEALTCHARE LIMITED (IN) | 2015-08-06 | — | — | WO | disclosed |
| EP-2822928-A1 | SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS | Dr. Reddy's Laboratories Ltd. (IN) | 2015-01-14 | — | — | EP | disclosed |
| CN-104133010-A | Method for separating and analyzing asimadoline intermediate and optical isomers by using HPLC | BEIJING VENTUREPHARM BIOTECH CORP | 2014-11-05 | — | — | CN | disclosed |
| CN-104133010-A | Method for separating and analyzing asimadoline intermediate and optical isomers by using HPLC | BEIJING VENTUREPHARM BIOTECH CORP | 2014-11-05 | — | — | CN | disclosed |
| US-20130303525-A1 | KAPPA OPIOID RECEPTOR AGONISTS | DR. REDDY'S LABORATORIES, INC. (US) | 2013-11-14 | — | — | US | disclosed |
| WO-2013131408-A1 | SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS | DR.REDDY'S LABORATORIES LTD. (IN) | 2013-09-12 | — | — | WO | disclosed |
| WO-2012012410-A2 | KAPPA OPIOID RECEPTOR AGONISTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001998-A1 | SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS | OPRK1, OPRL1, OPRD1 | F10 2769/4885F2 2834/4885PRSS1 2125/4885 |
| US-20130303525-A1 | KAPPA OPIOID RECEPTOR AGONISTS | OPRK1, OPRL1, OPRD1 | F10 2457/4885F2 2008/4885PRSS1 1119/4885 |
| US-10131655-B2 | Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists | OPRK1, OPRL1, OPRD1 | F10 2769/4885F2 2834/4885PRSS1 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.