Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.81 |
| ▸ | HTR1A | P08908 | 4/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | HTT | P42858 | 1/20 | 0.81 |
| ▸ | MPO | P05164 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | MC5R | P33032 | 1/20 | 0.59 |
| ▸ | MC3R | P41968 | 1/20 | 0.59 |
| ▸ | MC1R | Q01726 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | AHR | P35869 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29385251 | 0.90 | HTR2A (1.00) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL379409 | 0.90 | HTR2A (1.00) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL2684408 | 0.88 | HTR2A (0.97) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| Water SCHEMBL27796022 | 0.87 | HTR2A (0.93) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| Cyanide SCHEMBL29233340 | 0.85 | HTR2A (0.90) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL7004146 | 0.84 | HTR2A (0.71) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL7005718 | 0.84 | HTR2A (0.71) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL14094616 | 0.83 | HTR2A (0.61) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL19411654 | 0.83 | KDM4E (0.61) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL7889427 | 0.82 | HTR2A (0.69) | HTR2AHTR1AKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2722333-A1 | Spiro-indole derivatives for the treatment of parasitic diseases. | Novartis AG (CH) | 2014-04-23 | — | — | EP | disclosed |
| EP-2285808-B1 | SPIRO-INDOLE DERIVATIVES FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2013-11-20 | — | — | EP | disclosed |
| US-8399453-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-03-19 | — | — | US | disclosed |
| US-8399453-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-03-19 | — | — | US | disclosed |
| US-8399453-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-03-19 | — | — | US | disclosed |
| US-20110275613-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-11-10 | — | — | US | disclosed |
| US-20110275613-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-11-10 | — | — | US | disclosed |
| US-20110275613-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-11-10 | — | — | US | disclosed |
| US-8053442-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | disclosed |
| US-8053442-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | disclosed |
| EP-0848706-B1 | SUBSTITUTED BENZENE-FUSED HETEROCYCLICS AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2003-02-05 | — | — | EP | disclosed |
| EP-0848706-A1 | SUBSTITUTED BENZENE-FUSED HETERO- AND CARBOCYCLICS AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5691362-A | ANTIHISTAMINES, BRONCHODILATORS, ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL DISORDERS | SCHERING-PLOUGH CORPORATION (US) | 1997-11-25 | — | — | US | disclosed |
| WO-1996039383-A1 | SUBSTITUTED BENZENE-FUSED HETERO- AND CARBOCYCLICS AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |
| EP-0146787-B1 | INDOLE DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1988-08-17 | — | — | EP | disclosed |
| US-4616011-A | BRADYCARDIAL AND ANTIISCHEMIC AGENTS; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0146787-A2 | Indole derivatives, medicaments containing these compounds, and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-07-03 | — | — | EP | disclosed |
| US-4350634-A | HYPOTENSIVE AGENTS | SANDOZ LTD. (CH) | 1982-09-21 | — | — | US | disclosed |
| EP-0000355-B1 | NEW INDOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | SANDOZ AG (CH) | 1982-01-06 | — | — | EP | disclosed |
| EP-0000355-A1 | New indole derivatives, processes for their preparation, and pharmaceutical compositions containing them. | SANDOZ AG (CH) | 1979-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275613-A1 | ORGANIC COMPOUNDS | OTC, PC, OAT | HTR2A 4625/4885HTR1A 4697/4885KDM4E 1034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.