Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.76 |
| ▸ | MEN1 | O00255 | 4/20 | 0.76 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12488491 | 0.85 | MCL1 (0.70) | KMT2AMAPTMEN1CYP2C9LMNA | |
| SCHEMBL12488788 | 0.81 | MCL1 (0.78) | KMT2AMAPTMEN1MCL1 | |
| SCHEMBL1646792 | 0.79 | SORT1 (0.74) | KMT2AMAPTMEN1SORT1POLB | |
| SCHEMBL15920569 | 0.78 | SORT1 (1.00) | KMT2AMAPTMEN1SORT1POLB | |
| SCHEMBL22543377 | 0.77 | KMT2A (0.81) | KMT2AMAPTMEN1CYP2C9CYP1A2 | |
| SCHEMBL22542971 | 0.76 | KMT2A (0.81) | KMT2AMAPTMEN1CYP2C9CYP1A2 | |
| SCHEMBL23247097 | 0.76 | KMT2A (0.59) | KMT2AMAPTMEN1SORT1CYP2C9 | |
| SCHEMBL17364512 | 0.75 | SORT1 (0.61) | KMT2AMAPTMEN1SORT1L3MBTL1 | |
| SCHEMBL6034144 | 0.75 | SORT1 (0.72) | KMT2AMAPTMEN1SORT1POLB | |
| SCHEMBL4878207 | 0.75 | CYP11B2 (0.72) | KMT2AMAPTMEN1SORT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684167-B1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | EUTROPICS PHARMACEUTICALS INC (US) | 2020-09-09 | — | — | EP | disclosed |
| US-9345700-B2 | Compositions and methods useful for treating diseases | EUTROPICS PHARMACEUTICALS, INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20150352097-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | EUTROPICS PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | disclosed |
| US-9051305-B2 | Compositions and methods useful for treating diseases | EUTROPICS PHARMACEUTICALS, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20140221387-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | EUTROPICS PHARMACEUTICALS, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| EP-2684167-A2 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | Eutropics Pharmaceuticals, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |
| WO-2012122370-A2 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | EUTROPICS PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221387-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | BCL3, MCL1, BCL6 | KMT2A 1038/4885MAPT 3621/4885MEN1 720/4885 |
| US-20150352097-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | BCL3, MCL1, BCL6 | KMT2A 1038/4885MAPT 3621/4885MEN1 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.