Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 6/20 | 1.00 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646792 | 0.85 | SORT1 (0.74) | SORT1LRRK2KMT2AMAPTPOLB | |
| SCHEMBL29980628 | 0.84 | SORT1 (0.74) | SORT1 | |
| SCHEMBL23825504 | 0.84 | SORT1 (0.74) | SORT1 | |
| SCHEMBL4878207 | 0.84 | CYP11B2 (0.72) | SORT1LRRK2KMT2AMAPTPOLB | |
| SCHEMBL6034144 | 0.84 | SORT1 (0.72) | SORT1LRRK2KMT2AMAPTPOLB | |
| SCHEMBL18132518 | 0.83 | ALDH1A1 (0.72) | SORT1KMT2ACYP11B1CYP11B2MEN1 | |
| SCHEMBL15903391 | 0.82 | SORT1 (0.69) | SORT1LRRK2KMT2AMAPTPOLB | |
| SCHEMBL5950032 | 0.82 | KMT2A (0.71) | SORT1LRRK2KMT2AMAPTPOLB | |
| SCHEMBL29981095 | 0.80 | SORT1 (1.00) | SORT1 | |
| SCHEMBL15903147 | 0.80 | SORT1 (1.00) | SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948147-B1 | N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS | H LUNDBECK AS (DK) | 2019-03-13 | — | — | EP | disclosed |
| US-10195186-B2 | N-substituted-5-substituted phthalamic acids as sortilin inhibitors | H. LUNDBECK A/S (DK) | 2019-02-05 | — | — | US | disclosed |
| US-20170239226-A1 | N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors | H. LUNDBECK A/S (DK) | 2017-08-24 | — | — | US | disclosed |
| US-20170239226-A1 | N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors | H. LUNDBECK A/S (DK) | 2017-08-24 | — | — | US | disclosed |
| US-9682967-B2 | N-substituted-5-substituted phthalamic acids as sortilin inhibitors | H. LUNDBECK A/S (DK) | 2017-06-20 | — | — | US | disclosed |
| US-9682967-B2 | N-substituted-5-substituted phthalamic acids as sortilin inhibitors | H. LUNDBECK A/S (DK) | 2017-06-20 | — | — | US | disclosed |
| US-20150368231-A1 | N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS | H. LUNDBECK A/S (DK) | 2015-12-24 | — | — | US | disclosed |
| US-20150368231-A1 | N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS | H. LUNDBECK A/S (DK) | 2015-12-24 | — | — | US | disclosed |
| WO-2014114779-A1 | N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS | H. LUNDBECK A/S (DK) | 2014-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368231-A1 | N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS | SORT1, NRP1, SELPLG | SORT1 1/4885LRRK2 1219/4885KMT2A 3488/4885 |
| US-10195186-B2 | N-substituted-5-substituted phthalamic acids as sortilin inhibitors | SORT1, NRP1, SELPLG | SORT1 1/4885LRRK2 809/4885KMT2A 3639/4885 |
| US-20170239226-A1 | N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors | SORT1, NRP1, SELPLG | SORT1 1/4885LRRK2 809/4885KMT2A 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.