Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12525710 | 0.86 | APLNR (0.49) | APLNRTP53MMP8MMP12MMP13 | |
| SCHEMBL12493456 | 0.86 | MMP8 (0.50) | APLNRTP53MMP8MMP12MMP13 | |
| SCHEMBL12492811 | 0.86 | ALDH1A1 (0.53) | APLNRTP53MMP8MMP12MMP13 | |
| SCHEMBL15511710 | 0.81 | TP53 (0.45) | APLNRTP53MMP8MMP12MMP13 | |
| SCHEMBL28970344 | 0.79 | APLNR (0.58) | APLNRTP53HTR2AHTR2CALDH1A1 | |
| SCHEMBL12492637 | 0.79 | HTR2A (0.46) | APLNRTP53MMP8MMP12MMP13 | |
| SCHEMBL12493372 | 0.78 | APLNR (0.48) | APLNRTP53MEN1KMT2ANPC1 | |
| SCHEMBL28452492 | 0.77 | APLNR (0.63) | APLNRTP53MEN1KMT2AHTR2A | |
| SCHEMBL16735749 | 0.77 | APLNR (0.47) | APLNRTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL11300017 | 0.76 | TP53 (0.55) | APLNRTP53MEN1KMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2683703-A1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI (FR) | 2014-01-15 | — | — | EP | disclosed |
| WO-2012120057-A1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI (FR) | 2012-09-13 | — | — | WO | disclosed |