Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | ALPP | P05187 | 1/20 | 0.56 |
| ▸ | ALPG | P10696 | 1/20 | 0.56 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16421959 | 0.87 | KDM4E (0.73) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL14616345 | 0.85 | ALDH1A1 (0.58) | ALDH1A1KDM4EHSD17B10NPC1TSHR | |
| SCHEMBL15474489 | 0.84 | KDM4E (0.72) | ALDH1A1KDM4EHSD17B10NPC1TSHR | |
| SCHEMBL30951936 | 0.84 | ALDH1A1 (0.64) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL8268180 | 0.84 | KDM4E (0.67) | ALDH1A1KDM4EHSD17B10NPC1TSHR | |
| SCHEMBL5121884 | 0.84 | KDM4E (0.67) | ALDH1A1KDM4EHSD17B10NPC1TSHR | |
| SCHEMBL3587930 | 0.83 | KDM4E (0.69) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL3580770 | 0.82 | KDM4E (0.65) | ALDH1A1KDM4EHSD17B10NPC1LMNA | |
| SCHEMBL18968584 | 0.82 | KDM4E (0.64) | ALDH1A1KDM4EHSD17B10NPC1TSHR | |
| SCHEMBL12497263 | 0.82 | LMNA (0.69) | TSHRLMNAHTTGSK3BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017100525-A1 | SUBSTITUTED BENZIMIDAZOLIUM, PYRIDO-IMIDAZOLIUM, OR PYRAZINO-IMIDAZOLIUM COMPOUNDS AS CHEMOTHERAPEUTICS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-06-15 | — | — | WO | disclosed |
| US-20130289013-A1 | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS | SUNOVION PHARMACEUTICALS INC. | 2013-10-31 | — | — | US | disclosed |
| US-8497278-B2 | Imidazo[1,2-a]pyridine compounds | SUNOVION PHARMACEUTICALS INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-20110166146-A1 | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS | SUNOVION PHARMACEUTICALS INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166146-A1 | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS | PAICS, ITPA, DPYD | ALDH1A1 269/4885KDM4E 3088/4885HSD17B10 2559/4885 |
| US-20130289013-A1 | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS | PAICS, ITPA, DPYD | ALDH1A1 269/4885KDM4E 3088/4885HSD17B10 2559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.