Sugi Predict

Sugi Predict / Compounds / SCHEMBL12497355

SCHEMBL12497355

SCHEMBL12497355

CCOP(=O)(CC(=O)Nc1ccccc1NC(=O)O)OCC

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.47
▸ POLB P06746 1/20 0.47
▸ TSHR P16473 3/20 0.45
▸ MAPK10 P53779 1/20 0.45
▸ HSD17B10 Q99714 3/20 0.45
▸ GAA P10253 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ MAPK1 P28482 3/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ HPGD P15428 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ PTK2 Q05397 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4817806 0.88 HPGD (0.53) KDM4EPOLBHSD17B10MAPK1ALDH1A1
SCHEMBL13653517 0.85 GAA (0.51) KDM4ETSHRHSD17B10GAAMAPK1
SCHEMBL10952765 0.83 NPSR1 (0.53) KDM4EHSD17B10GAAMAPK1NPSR1
SCHEMBL15483137 0.82 LMNA (0.41) KDM4EPOLBGAAMAPK1ALDH1A1
SCHEMBL13653001 0.81 ALDH1A1 (0.51) KDM4EPOLBCYP2C19MAPK1ALDH1A1
SCHEMBL28463477 0.80 GAA (0.48) POLBTSHRHSD17B10GAACYP2C19
SCHEMBL16766556 0.79 PTK2 (0.38) KDM4EPOLBTSHRMAPK10GAA
SCHEMBL13966687 0.78 NPC1 (0.53) KDM4EPOLBGAAALDH1A1KMT2A
SCHEMBL31345023 0.78 MEN1 (0.51) POLBGAACYP2C19MAPK1ALDH1A1
SCHEMBL28046922 0.76 GAA (0.44) KDM4EPOLBTSHRHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10981933-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2021-04-20 — — US disclosed
EP-3695836-A1 HISTONE DEACETYLASE INHIBITORS BioMarin Pharmaceutical Inc. (US) 2020-08-19 — — EP disclosed
US-20200148704-A1 HISTONE DEACETYLASE INHIBITORS BIOMARIN PHARMACEUTICAL INC. 2020-05-14 — — US disclosed
EP-3524324-A1 HISTONE DEACETYLASE INHIBITORS BioMarin Pharmaceutical Inc. (US) 2019-08-14 — — EP disclosed
US-20190233439-A1 HISTONE DEACETYLASE INHIBITORS REPLIGEN CORPORATION 2019-08-01 — — US disclosed
US-10301323-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2019-05-28 — — US disclosed
US-10280182-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2019-05-07 — — US disclosed
EP-2680694-B1 HISTONE DEACETYLASE INHIBITORS BIOMARIN PHARM INC (US) 2019-01-02 — — EP disclosed
US-20180370987-A1 HISTONE DEACETYLASE INHIBITORS REPLIGEN CORPORATION 2018-12-27 — — US disclosed
US-20180327423-A1 HISTONE DEACETYLASE INHIBITORS REPLIGEN CORPORATION 2018-11-15 — — US disclosed
US-20170050984-A1 HISTONE DEACETYLASE INHIBITORS REPLIGEN CORPORATION 2017-02-23 — — US disclosed
US-20170044186-A1 HISTONE DEACETYLASE INHIBITORS BIOMARIN PHARMACEUTICAL INC. 2017-02-16 — — US disclosed
US-9540395-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2017-01-10 — — US disclosed
EP-2968251-A1 HISTONE DEACETYLASE INHIBITORS BioMarin Pharmaceutical Inc. (US) 2016-01-20 — — EP disclosed
US-8957066-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2015-02-17 — — US disclosed
WO-2014152444-A1 HISTONE DEACETYLASE INHIBITORS BIOMARIN PHARMACEUTICAL INC. (US) 2014-09-25 — — WO disclosed
US-20140051680-A1 Histone Deacetylase Inhibitors REPLIGEN CORPORATION (US) 2014-02-20 — — US disclosed
EP-2680694-A1 HISTONE DEACETYLASE INHIBITORS REPLIGEN CORPORATION (US) 2014-01-08 — — EP disclosed
US-20130317003-A1 Histone Deacetylase Inhibitors BIOMARIN PHARMACEUTICAL INC. 2013-11-28 — — US disclosed
WO-2012118782-A1 HISTONE DEACETYLASE INHIBITORS REPLIGEN CORPORATION (US) 2012-09-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170044186-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-20190233439-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-20140051680-A1 Histone Deacetylase Inhibitors HDAC1, HDAC2, HDAC3 KDM4E 157/4885POLB 2724/4885TSHR 3136/4885
US-10301323-B2 Histone deacetylase inhibitors HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-20200148704-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-10280182-B2 Histone deacetylase inhibitors HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-20180327423-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-10981933-B2 Histone deacetylase inhibitors HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-20180370987-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-20130317003-A1 Histone Deacetylase Inhibitors HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885
US-20170050984-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885POLB 2567/4885TSHR 3182/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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