Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 13/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81349 | 0.82 | ADRB1 (0.48) | TGFBR1ACVR1KCNH2GHSRHTT | |
| SCHEMBL81695 | 0.82 | ADRB1 (0.48) | TGFBR1ACVR1KCNH2GHSRHTT | |
| SCHEMBL18711251 | 0.80 | SIGMAR1 (0.46) | TGFBR1ACVR1KCNH2GHSRHTT | |
| SCHEMBL16069835 | 0.80 | MAPT (0.47) | TGFBR1ACVR1KCNH2GHSRHTT | |
| SCHEMBL2446299 | 0.80 | MAPT (0.47) | TGFBR1ACVR1KCNH2GHSRHTT | |
| SCHEMBL3528425 | 0.80 | MAPT (0.47) | TGFBR1ACVR1KCNH2GHSRHTT | |
| SCHEMBL6367230 | 0.80 | HTR3E (0.47) | TGFBR1ACVR1KCNH2LTA4HGHSR | |
| SCHEMBL2549111 | 0.80 | GHSR (0.53) | CDK4CCND1TGFBR1ACVR1KCNH2 | |
| SCHEMBL578246 | 0.80 | GHSR (0.53) | CDK4CCND1TGFBR1ACVR1KCNH2 | |
| SCHEMBL6367231 | 0.80 | HTR3E (0.47) | TGFBR1ACVR1KCNH2LTA4HGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048411-A1 | PLK-4 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2012-04-19 | — | — | WO | disclosed |