Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498738 | 0.90 | MAPT (0.47) | MAPTKDM4EMEN1HSP90AA1KMT2A | |
| SCHEMBL12499717 | 0.87 | KDM4E (0.46) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL12499656 | 0.85 | MAPT (0.43) | MAPTKDM4EMEN1HSP90AA1CRHBP | |
| SCHEMBL12499852 | 0.84 | PTGES (0.43) | MAPTKDM4EKMT2AALOX5ALDH1A1 | |
| SCHEMBL12499736 | 0.84 | SRD5A2 (0.46) | MEN1KMT2ALMNAPOLB | |
| SCHEMBL12499891 | 0.81 | KMT2A (0.51) | MAPTKDM4EMEN1KMT2AALOX5 | |
| SCHEMBL12499839 | 0.79 | LMNA (0.43) | MAPTKDM4EMEN1HSP90AA1CRHBP | |
| SCHEMBL12498729 | 0.77 | SRD5A2 (0.46) | ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL20427919 | 0.76 | PDE4D (0.43) | MAPTKDM4EKMT2AALDH1A1LMNA | |
| SCHEMBL24208609 | 0.75 | IDH1 (0.45) | MAPTKDM4EMEN1HSP90AA1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103071-A2 | COMPOUNDS AND COMPOSITIONS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-02 | — | — | WO | disclosed |