Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499319 | 0.88 | KDM4E (0.43) | MAPTKDM4EMEN1KMT2APOLB | |
| SCHEMBL12499698 | 0.87 | MAPT (0.47) | MAPTALOX5KDM4EHSP90AA1KMT2A | |
| SCHEMBL12499879 | 0.85 | MAPT (0.46) | MAPTALOX5KDM4EMEN1HSP90AA1 | |
| SCHEMBL12499317 | 0.85 | SRD5A2 (0.43) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL12499589 | 0.82 | ALOX5 (0.43) | MAPTALOX5KDM4EMEN1KMT2A | |
| SCHEMBL12499839 | 0.76 | LMNA (0.43) | MAPTKDM4EMEN1HSP90AA1CRHBP | |
| SCHEMBL12498738 | 0.76 | MAPT (0.47) | MAPTALOX5KDM4EMEN1HSP90AA1 | |
| SCHEMBL24208609 | 0.75 | IDH1 (0.45) | MAPTALOX5KDM4EMEN1HSP90AA1 | |
| SCHEMBL12498729 | 0.74 | SRD5A2 (0.46) | POLBALDH1A1LMNAIDH1 | |
| SCHEMBL12499717 | 0.73 | KDM4E (0.46) | MAPTKDM4EMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103071-A2 | COMPOUNDS AND COMPOSITIONS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-02 | — | — | WO | disclosed |