SCHEMBL12500466

SCHEMBL12500466

CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCNC(=O)C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
EPHX1 P07099 1/20 0.31
CA14 Q9ULX7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6045455 0.90 ALDH1A1 (0.41) MEN1KMT2AALDH1A1POLBSMN1; SMN2
SCHEMBL714350 0.86 MEN1 (0.43) MEN1KMT2AALDH1A1POLBSMN1; SMN2
SCHEMBL14761935 0.86 MEN1 (0.37) MEN1KMT2A
SCHEMBL24496462 0.86 MEN1 (0.37) MEN1KMT2A
SCHEMBL15185748 0.83 MEN1 (0.35) MEN1KMT2A
SCHEMBL15185749 0.83 MEN1 (0.35) MEN1KMT2A
SCHEMBL27052880 0.81 MEN1 (0.38) MEN1KMT2AALDH1A1POLBSMN1; SMN2
SCHEMBL14286753 0.80
SCHEMBL15617410 0.79
SCHEMBL18349839 0.77 EPHX1 (0.36) MEN1KMT2AALDH1A1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11591594-B2 LNA-G process ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) 2023-02-28 US claimed
EP-3341479-B1 LNA-G PROCESS ROCHE INNOVATION CT COPENHAGEN AS (DK) 2019-12-18 EP claimed
US-20190055550-A1 LNA-G Process ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2019-02-21 US claimed
US-11591594-B2 LNA-G process ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) 2023-02-28 US disclosed
US-20200318109-A1 LNA-G Process F. HOFFMANN-LA ROCHE AG (CH) 2020-10-08 US disclosed
EP-3341479-B1 LNA-G PROCESS ROCHE INNOVATION CT COPENHAGEN AS (DK) 2019-12-18 EP disclosed
US-20190055550-A1 LNA-G Process ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2019-02-21 US disclosed
US-9803184-B2 Method for immobilizing nucleic ligands LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES (FR) 2017-10-31 US disclosed
EP-2658864-A1 METHOD FOR IMMOBILISING NUCLEIC LIGANDS LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES (Groupement d Interet public) (FR) 2013-11-06 EP disclosed
WO-2012090183-A1 METHOD FOR IMMOBILISING NUCLEIC LIGANDS LFB BIOTECHNOLOGIES (FR) 2012-07-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200318109-A1 LNA-G Process OGG1, DUT, FBL MEN1 1317/4885KMT2A 501/4885ALDH1A1 2120/4885
US-11591594-B2 LNA-G process OGG1, DUT, FBL MEN1 1251/4885KMT2A 452/4885ALDH1A1 2255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.