Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12502459 | 0.86 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL13754058 | 0.84 | MMP1 (0.70) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL5147840 | 0.83 | USP2 (0.67) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL10495065 | 0.81 | NPC1 (0.88) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL21595955 | 0.80 | NPC1 (0.73) | NPC1SMN1; SMN2HPGDPOLBUSP2 | |
| SCHEMBL10294638 | 0.80 | RAB9A (0.75) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| Hydrochloric Acid SCHEMBL12502756 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL12502477 | 0.80 | PARP10 (0.65) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL11424416 | 0.79 | NPC1 (0.93) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL21596070 | 0.79 | MTNR1A (0.75) | NPC1RAB9ASMN1; SMN2USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670734-A1 | NOVEL ETHER LINKED COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE | UNIVERSITY OF NOTTINGHAM (GB) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104659-A1 | NOVEL ETHER LINKED COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE | UNIVERSITY OF NOTTINGHAM (GB) | 2012-08-09 | — | — | WO | disclosed |