Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 2/20 | 0.48 |
| ▸ | FAP | Q12884 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503519 | 0.82 | POLB (0.70) | GAAPREPFAPDPP4POLB | |
| SCHEMBL1853141 | 0.78 | RIPK1 (0.69) | EPHX2RIPK1HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL1847627 | 0.78 | RIPK1 (0.69) | EPHX2RIPK1HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL17558248 | 0.78 | RIPK1 (0.69) | EPHX2RIPK1HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL3511378 | 0.77 | HCRTR1 (0.43) | EPHX2GAAPREPFAPDPP4 | |
| SCHEMBL3513867 | 0.77 | TRPV1 (0.52) | GAAPREPFAPPOLB | |
| SCHEMBL3062584 | 0.77 | RIPK1 (0.67) | EPHX2RIPK1HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL8596155 | 0.76 | PARP14 (0.62) | RIPK1GAAHSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL28257267 | 0.75 | HSD11B1 (0.61) | EPHX2RIPK1HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL21312423 | 0.75 | RIPK1 (0.65) | EPHX2RIPK1HSD11B1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |