Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 5/20 | 0.42 |
| ▸ | ABL2 | P42684 | 5/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12500775 | 0.85 | EGFR (0.57) | EGFRKDRTRPA1ABL1ABL2 | |
| SCHEMBL1896112 | 0.83 | EGFR (0.75) | EGFRKDRTRPA1ABL1ABL2 | |
| SCHEMBL1890769 | 0.79 | EGFR (0.66) | EGFRKDRTRPA1ABL1ABL2 | |
| SCHEMBL1899168 | 0.76 | KDR (0.77) | EGFRKDRTRPA1LIMK1 | |
| SCHEMBL1895100 | 0.74 | EGFR (0.62) | EGFRKDRTRPA1ABL1ABL2 | |
| SCHEMBL1891363 | 0.73 | TRPA1 (0.62) | EGFRKDRTRPA1ABL1ABL2 | |
| SCHEMBL12410639 | 0.71 | EGFR (0.55) | EGFRKDRTRPA1ABL1ABL2 | |
| SCHEMBL2462868 | 0.66 | EGFR (1.00) | EGFRKDRABL1ABL2PRKCA | |
| SCHEMBL10139164 | 0.65 | MEN1 (0.54) | — | |
| SCHEMBL13639098 | 0.64 | NOS3 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-20110118470-A1 | NITROGEN-CONTAINING AROMATIC DERIVATIVES | FUNAHASHI YASUHIRO | 2011-05-19 | — | — | US | disclosed |
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | EGFR 790/4885KDR 2687/4885TRPA1 1526/4885 |
| US-20110118470-A1 | NITROGEN-CONTAINING AROMATIC DERIVATIVES | GNG2, GCG, FRG1 | EGFR 795/4885KDR 2782/4885TRPA1 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.