Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149959 | 0.87 | TSHR (0.52) | TSHRTHRBALDH1A1POLBAPEX1 | |
| Methacrylic Acid SCHEMBL8175854 | 0.82 | TSHR (0.47) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL8982469 | 0.81 | TSHR (0.46) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL5140617 | 0.81 | TSHR (0.50) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL15006942 | 0.80 | THRB (0.63) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL9312193 | 0.80 | TSHR (0.44) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL12286354 | 0.79 | TSHR (0.52) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL22465839 | 0.79 | TSHR (0.47) | TSHRTHRBALDH1A1POLBAPEX1 | |
| Methacrylic Acid SCHEMBL28661459 | 0.78 | TSHR (0.43) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL746457 | 0.78 | THRB (0.55) | TSHRTHRBALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397505-A1 | High water content silicone hydrogels | Bausch & Lomb Incorporated (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2222736-B1 | HIGH WATER CONTENT SILICONE HYDROGELS | BAUSCH & LOMB (US) | 2011-09-21 | — | — | EP | disclosed |
| US-7934830-B2 | High water content silicone hydrogels | BAUSCH & LOMB INCORPORATED (US) | 2011-05-03 | — | — | US | disclosed |
| US-7884141-B2 | hydrogel contact lenses formed from esterified aminoalcohol monomers; improved surface wettability, water absorption to silicone hydrogel, and decreased accumulation of protein deposits (lysozyme), and reduced absorption of charged biocides which leads to ocular staining | BAUSCH & LOMB INCORPORATED (US) | 2011-02-08 | — | — | US | disclosed |
| EP-2222736-A1 | HIGH WATER CONTENT SILICONE HYDROGELS | Bausch & Lomb Incorporated (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-2215501-A1 | BIOMEDICAL DEVICES | Bausch & Lomb Incorporated (US) | 2010-08-11 | — | — | EP | disclosed |
| EP-2121450-A1 | PACKAGING SYSTEM FOR CONTACT LENSES | Bausch & Lomb Incorporated (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2009073321-A1 | HIGH WATER CONTENT SILICONE HYDROGELS | BAUSCH & LOMB INCORPORATED (US) | 2009-06-11 | — | — | WO | disclosed |
| US-20090141234-A1 | High Water Content Silicone Hydrogels | BAUSCH HEALTH AMERICAS, INC. | 2009-06-04 | — | — | US | disclosed |
| WO-2009064589-A1 | BIOMEDICAL DEVICES | BAUSCH & LOMB INCORPORATED (US) | 2009-05-22 | — | — | WO | disclosed |
| EP-1236068-B1 | CONTACT LENS | NOVARTIS AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2008079716-A1 | PACKAGING SYSTEM FOR CONTACT LENSES | BAUSCH & LOMB INCORPORATED (US) | 2008-07-03 | — | — | WO | disclosed |
| US-20080152540-A1 | PACKAGING SOLUTIONS | BAUSCH & LOMB INCORPORATED (US) | 2008-06-26 | — | — | US | disclosed |
| US-7201481-B2 | Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer | NOVARTIS AG (CH) | 2007-04-10 | — | — | US | disclosed |
| EP-1236068-A4 | CONTACT LENS | NOVARTIS AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| US-20060012751-A1 | Contact lens | ALCON INC. (CH) | 2006-01-19 | — | — | US | disclosed |
| US-6649722-B2 | Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer | NOVARTIS AG (CH) | 2003-11-18 | — | — | US | disclosed |
| EP-1236068-A1 | CONTACT LENS | Novartis AG (CH) | 2002-09-04 | — | — | EP | disclosed |
| US-20020107337-A1 | Contact lens | ALCON INC. (CH) | 2002-08-08 | — | — | US | disclosed |
| WO-2001042846-A1 | CONTACT LENS | WESLEY JESSEN CORPORATION (US) | 2001-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080152540-A1 | PACKAGING SOLUTIONS | AQP1, ARGLU1, CRYZ | TSHR 3664/4885THRB 4452/4885ALDH1A1 4081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.