Sugi Predict

Sugi Predict / Compounds / SCHEMBL12508238

SCHEMBL12508238

SCHEMBL12508238

Cc1ccc(NS(C)(=O)=O)nc1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 7/20 0.58
▸ ALDH1A1 P00352 6/20 0.58
▸ MAPT P10636 3/20 0.58
▸ HPGD P15428 2/20 0.58
▸ GAA P10253 1/20 0.58
▸ KMT2A Q03164 2/20 0.54
▸ RAB9A P51151 2/20 0.53
▸ EDNRA P25101 1/20 0.48
▸ ATM Q13315 1/20 0.46
▸ MEN1 O00255 1/20 0.44
▸ PIK3CG P48736 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5632130 0.82 KDM4E (0.57) KDM4EALDH1A1MAPTHPGDGAA
SCHEMBL30834883 0.81 KDM4E (0.59) KDM4EALDH1A1MAPTHPGDGAA
SCHEMBL27182828 0.81 ALDH1A1 (0.55) KDM4EALDH1A1MAPTHPGDGAA
SCHEMBL3486122 0.79 ALDH1A1 (0.82) KDM4EALDH1A1MAPTHPGDGAA
SCHEMBL31748788 0.79 ALDH1A1 (0.82) KDM4EALDH1A1MAPTHPGDGAA
SCHEMBL7351894 0.78 CA12 (0.46) KDM4EALDH1A1MAPTHPGDGAA
SCHEMBL12266080 0.78 ALDH1A1 (0.54) KDM4EALDH1A1MAPTKMT2ARAB9A
SCHEMBL12018120 0.78 KDM4E (0.60) KDM4EALDH1A1KMT2AEDNRAMEN1
SCHEMBL1973088 0.78 DEGS1 (0.46) PIK3CG
SCHEMBL12017954 0.78 ABL1 (0.48) PIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113490668-B Compounds and compositions for the treatment of diseases associated with APJ receptor activity 安娜普尔纳生物股份有限公司 2025-02-25 — — CN disclosed
WO-2023220238-A1 LRRK2 INHIBITORS INTERLINE THERAPEUTICS, INC. (US) 2023-11-16 — — WO disclosed
WO-2023081854-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 — — WO disclosed
WO-2023081845-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 — — WO disclosed
US-11352359-B2 PI3K protein kinase inhibitors RHIZEN PHARMACEUTICALS AG (CH) 2022-06-07 — — US disclosed
CN-109020887-B Amide compounds as agents for the prophylaxis and treatment of psychotic disorders 绍兴从零医药科技有限公司 2022-03-01 — — CN disclosed
WO-2021226519-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2021-11-11 — — WO disclosed
WO-2021226477-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2021-11-11 — — WO disclosed
CN-113490668-A Compounds and compositions for treating diseases associated with APJ receptor activity 安娜普尔纳生物股份有限公司 2021-10-08 — — CN disclosed
US-20210032236-A1 NOVEL GLUTAMINASE INHIBITORS RHIZEN PHARMACEUTICALS AG (CH) 2021-02-04 — — US disclosed
WO-2015001491-A1 PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS RHIZEN PHARMACEUTICALS SA (CH) 2015-01-08 — — WO disclosed
US-20140213585-A1 PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES RIGEL PHARMACEUTICALS, INC. (US) 2014-07-31 — — US disclosed
US-8735418-B2 Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases RIGEL PHARMACEUTICALS, INC. (US) 2014-05-27 — — US disclosed
US-8445167-B2 Metal phthalocyanine dye mixture, curable composition, color filter, and method for producing color filter FUJIFILM CORPORATION (JP) 2013-05-21 — — US disclosed
US-20110172415-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP SHIONOGI & CO., LTD. (JP) 2011-07-14 — — US disclosed
US-7935706-B2 Nitrogen-containing heterocycle derivatives substituted with cyclic group SHIONOGI & CO., LTD. (JP) 2011-05-03 — — US disclosed
US-7935706-B2 Nitrogen-containing heterocycle derivatives substituted with cyclic group SHIONOGI & CO., LTD. (JP) 2011-05-03 — — US disclosed
US-20090062261-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP SHIONOGI & CO., LTD. (JP) 2009-03-05 — — US disclosed
US-20090062261-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP SHIONOGI & CO., LTD. (JP) 2009-03-05 — — US disclosed
EP-1988077-A1 NIROGENOUS HETEROCYCLIC DERIVATIVES SUBSTITUTED WITH CYCLIC GROUPS SHIONOGI & CO., LTD. (JP) 2008-11-05 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11352359-B2 PI3K protein kinase inhibitors PIK3CD, PIK3R5, PIK3CB KDM4E 3414/4885ALDH1A1 4545/4885MAPT 3323/4885
US-20110172415-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP NR4A1, NR0B2, NR0B1 KDM4E 2461/4885ALDH1A1 2355/4885MAPT 3860/4885
US-20210032236-A1 NOVEL GLUTAMINASE INHIBITORS GLS, GLS2, GLUL KDM4E 2096/4885ALDH1A1 1082/4885MAPT 2866/4885
US-20140213585-A1 PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES JAK2, JAK1, JAK3 KDM4E 1032/4885ALDH1A1 3219/4885MAPT 3560/4885
US-20090062261-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP NR4A1, NR0B2, NR0B1 KDM4E 2461/4885ALDH1A1 2355/4885MAPT 3860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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