Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12887742 | 0.88 | PTGS1 (0.38) | PTGS1NR1H3NR1H2PTPN1RXRA | |
| SCHEMBL280145 | 0.88 | PTGS1 (0.38) | PTGS1NR1H3NR1H2PTPN1CYP3A4 | |
| SCHEMBL280416 | 0.87 | PTGS1 (0.39) | PTGS1NR1H3NR1H2PTPN1CYP3A4 | |
| SCHEMBL280417 | 0.83 | PTGS1 (0.37) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL10225176 | 0.82 | SOD1 (0.47) | PTGS1NR1H3NR1H2PTPN1CYP3A4 | |
| SCHEMBL280154 | 0.82 | SOD1 (0.47) | PTGS1NR1H3NR1H2PTPN1CYP3A4 | |
| SCHEMBL280188 | 0.82 | SOD1 (0.47) | PTGS1NR1H3NR1H2PTPN1CYP3A4 | |
| SCHEMBL280147 | 0.79 | NR1H3 (0.44) | PTGS1NR1H3NR1H2PTPN1RXRA | |
| SCHEMBL10217012 | 0.77 | PTGS1 (0.54) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL267647 | 0.74 | PTGS1 (0.43) | PTGS1NR1H3NR1H2PTPN1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238634-A1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238634-A1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | IL1A, IL1B, TNF | PTGS1 20/4885NR1H3 3538/4885NR1H2 2512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.