Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.31 |
| ▸ | POLA1 | P09884 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280416 | 0.90 | PTGS1 (0.39) | PTGS1NR1H3NR1H2PTPN1MEN1 | |
| SCHEMBL12522438 | 0.88 | PTGS1 (0.39) | PTGS1NR1H3NR1H2PTPN1MEN1 | |
| SCHEMBL280417 | 0.85 | PTGS1 (0.37) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL12887742 | 0.85 | PTGS1 (0.38) | PTGS1NR1H3NR1H2PTPN1RXRA | |
| SCHEMBL280336 | 0.79 | PTGS1 (0.53) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL280188 | 0.79 | SOD1 (0.47) | PTGS1NR1H3NR1H2PTPN1MEN1 | |
| SCHEMBL280154 | 0.79 | SOD1 (0.47) | PTGS1NR1H3NR1H2PTPN1MEN1 | |
| SCHEMBL10225176 | 0.79 | SOD1 (0.47) | PTGS1NR1H3NR1H2PTPN1MEN1 | |
| SCHEMBL280147 | 0.78 | NR1H3 (0.44) | PTGS1NR1H3NR1H2PTPN1RXRA | |
| SCHEMBL280289 | 0.73 | KARS1 (0.39) | PTGS1NR1H3PTPN1MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133915-B2 | Interleukin-1 and tumor necrosis factor-α modulators; syntheses of such modulators and methods of using such modulators | NEREUS PHARMACEUTICALS, INC. (US) | 2012-03-13 | — | — | US | disclosed |