SCHEMBL12528554

SCHEMBL12528554

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(I)nn1-c1ncccc1Cl

nearest known ligand 0.80

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 4/20 0.38
DHODH Q02127 1/20 0.38
F10 P00742 1/20 0.36
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
HTT P42858 1/20 0.34
NTRK1 P04629 3/20 0.34
TRPV1 Q8NER1 1/20 0.34
GRM4 Q14833 2/20 0.33
GRM1 Q13255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL952862 0.92 DHODH (0.37) MALT1DHODHF10NPC1RAB9A
SCHEMBL782485 0.91 MALT1 (0.39) MALT1DHODHF10NPC1RAB9A
SCHEMBL12528142 0.91 KMT2A (0.40) MALT1DHODHF10NTRK1
SCHEMBL12911688 0.90 DHODH (0.36) MALT1DHODHF10NPC1RAB9A
Chlorantraniliprole SCHEMBL29551 0.89 DHODH (0.44) MALT1DHODHF10NPC1RAB9A
SCHEMBL12935740 0.89 MALT1 (0.38) MALT1DHODHF10NPC1RAB9A
Chlorantraniliprole SCHEMBL29363261 0.89 DHODH (0.44) MALT1DHODHF10NPC1RAB9A
SCHEMBL13072407 0.89 ALDH1A1 (0.37) MALT1DHODHF10
SCHEMBL12912103 0.87 MALT1 (0.36) MALT1DHODHF10NPC1RAB9A
SCHEMBL782368 0.86 CARM1 (0.39) MALT1F10TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 MALT1 4856/4885DHODH 771/4885F10 2564/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT MALT1 4865/4885DHODH 284/4885F10 3713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.