Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 20/20 | 0.86 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12531442 | 1.00 | CCR5 (0.86) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL12531266 | 0.93 | CCR5 (0.84) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL10073296 | 0.92 | CCR5 (1.00) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL10073314 | 0.92 | CCR5 (0.81) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL10073382 | 0.90 | CCR5 (0.80) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL12796167 | 0.88 | CCR5 (0.83) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL12531292 | 0.87 | CCR5 (0.86) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL10073306 | 0.86 | CCR5 (0.75) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL14964382 | 0.86 | CCR5 (0.65) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL10073421 | 0.85 | CCR5 (0.72) | CCR5CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130129626-A1 | IN VIVO IMAGING AGENTS | HAMMERSMITH IMANET LIMITED (GB) | 2013-05-23 | — | — | US | disclosed |
| US-20130129625-A1 | IN VIVO IMAGING AGENTS | HAMMERSMITH IMANET LIMITED (GB) | 2013-05-23 | — | — | US | disclosed |
| US-20110129419-A1 | IN VIVO IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2011-06-02 | — | — | US | disclosed |
| US-20110129419-A1 | IN VIVO IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2011-06-02 | — | — | US | disclosed |
| US-20110059154-A1 | CCR5 ANTAGONISTS AS PROPHYLACTICS FOR PREVENTING HIV INFECTION AND METHODS OF INHIBITING TRANSMISSION OF SAME | MERCK SHARP & DOHME CORP. | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059154-A1 | CCR5 ANTAGONISTS AS PROPHYLACTICS FOR PREVENTING HIV INFECTION AND METHODS OF INHIBITING TRANSMISSION OF SAME | CCR5, CCL5, CCR2 | CCR5 1/4885CHRM2 322/4885CHRM1 305/4885 |
| US-20110129419-A1 | IN VIVO IMAGING AGENTS | CCR5, CCR2, CX3CR1 | CCR5 1/4885CHRM2 1260/4885CHRM1 1805/4885 |
| US-20130129625-A1 | IN VIVO IMAGING AGENTS | CCR5, CCR2, CX3CR1 | CCR5 1/4885CHRM2 1260/4885CHRM1 1805/4885 |
| US-20130129626-A1 | IN VIVO IMAGING AGENTS | CCR5, CCR2, CX3CR1 | CCR5 1/4885CHRM2 1260/4885CHRM1 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.